Synthetic biology is an increasingly high-profile area of research that can be understood as encompassing three broad approaches towards the synthesis of living systems: DNA-based device construction, genome-driven cell engineering and protocell creation. Each approach is characterized by different aims, methods and constructs, in addition to a range of positions on intellectual property and regulatory regimes. We identify subtle but important differences between the schools in relation to their treatments of genetic determinism, cellular context and complexity. These distinctions tie into (...) two broader issues that define synthetic biology: the relationships between biology and engineering, and between synthesis and analysis. These themes also illuminate synthetic biology's connections to genetic and other forms of biological engineering, as well as to systems biology. We suggest that all these knowledge-making distinctions in synthetic biology raise fundamental questions about the nature of biological investigation and its relationship to the construction of biological components and systems. (shrink)

Synthetic biology is an increasingly high‐profile area of research that can be understood as encompassing three broad approaches towards the synthesis of living systems: DNA‐based device construction, genome‐driven cell engineering and protocell creation. Each approach is characterized by different aims, methods and constructs, in addition to a range of positions on intellectual property and regulatory regimes. We identify subtle but important differences between the schools in relation to their treatments of genetic determinism, cellular context and complexity. These distinctions tie into (...) two broader issues that define synthetic biology: the relationships between biology and engineering, and between synthesis and analysis. These themes also illuminate synthetic biology's connections to genetic and other forms of biological engineering, as well as to systems biology. We suggest that all these knowledge‐making distinctions in synthetic biology raise fundamental questions about the nature of biological investigation and its relationship to the construction of biological components and systems. BioEssays 30:57–65, 2008. © 2007 Wiley Periodicals, Inc. (shrink)

It was love at first sight when Jonathan Calvert saw the Matterhorn in 1953. Something in the way the mountain held sway over him inspired a lifelong passion for natural beauty and adventure. Over the next fifty years, Calvert climbed, hiked, trekked, sailed, kayaked, and dog-sledded in wild places across the globe, following his urge to know. And he hasn t quit yet. In July 2014, he will spend a month in Central Asia traveling the Silk Road (...) through the Pamirs and Tian Shan mountains. In 2015 Calvert returns to the Antarctic in a sailboat to kayak and camp. This book is a record of his adventures, told through memoir, journals, and photographs. Calvert has devoted his life to exploring the world and himself, and he has never gotten to the bottom of the wellspring that is curiosity. Calvert has walked in the footsteps of early explorers, camped above the clouds, come face-to-tusk with a walrus, and, within yards of a summit, talked down the inner voice that cajoled him to quit. He has stumbled into crevasses, kayaked in quiet waters above whales, suffered altitude sickness, and called his family via radio and cell phone relay from a precipitous ledge to say, I made it. Discovering early in life that striking out by himself got the job done best, Calvert is no stranger to singular travels and travails. Yes, he adventures with comrades roped in as a team, paddling together, or taking his turn at the ship s helm but ultimately the journey is one s own. Throughout his life, Calvert has jumped at chance after chance, among them: climbing Alaska s Mount McKinley, Argentina s Aconcagua, and mountains in Switzerland, France, Tanzania, and Nepal; trekking in Tibet, Bhutan, England, and Pakistan; and kayaking the coast of Greenland and the Zhupanova River in the Kamchatka Peninsula. Where s that? Explore these pages, and then you will know.". (shrink)

A central figure in Western history and American political thought, Thomas Paine continues to provoke debate among politicians, activists, and scholars. People of all ideological stripes are inspired by his trenchant defense of the rights and good sense of ordinary individuals, and his penetrating critiques of arbitrary power. This volume contains Paine’s explosive _Common Sense_ in its entirety, including the oft-ignored Appendix, as well as selections from his other major writings: _The American Crisis_, _Rights of Man,_ and _The Age of (...) Reason. _It also contains several of Paine’s shorter essays. All the documents have been transcribed directly from the originals, making this edition the most reliable one available. Essays by Ian Shapiro, Jonathan Clark, Jane Calvert, and Eileen Hunt Botting bring Paine into sharp focus, illuminating his place in the tumultuous decades surrounding the American and French Revolutions and his larger historical legacy. (shrink)

Ever since Bishop Stillingfleet accused John Locke of having unwittingly paved the way with his Essay for the alleged heresy promulgated in John Toland's Christianity Not Mysterious, the latter two thinkers and works have been consistently joined in histories of philosophy covering the rise of natural religion in England. While scholars have generally thought that Locke got the better of the good bishop in their subsequent written exchanges initiated by the charge, they appear merely to assume that Stillingfleet correctly read (...) Toland and that Locke accepts that reading. Perhaps the most obvious piece of evidence favoring that stance is that while Locke clearly admits "above reason" doctrines, Toland dismisses them: Christianity is not mysterious! It is curious, however, that Toland scholars readily point out many concepts that Toland used as being the same as or different from Lockean notions about which many Locke scholars are admittedly perplexed. Through patient exposition of relevant texts and letters, deconstruction of scholarly works, and careful reasoning, this book shows that Toland's deviations from Locke regarding reason and faith are far more minor than anyone has concluded. Stillingfleet was correct to connect them, but was incorrect in the way that he did it. (shrink)

In Contentious Rituals, Jonathan S. Blake focuses on Protestant parades in the streets of Northern Ireland and why people choose to participate in them. Drawing on rich interviews, survey data, and ethnographic observations, Blake presents a new look at the conflict in Northern Ireland and offers findings that illuminate contested symbols everywhere.

Embodied cognition has attracted significant attention within cognitive science and related fields in recent years. It is most noteworthy for its emphasis on the inextricable connection between mental functioning and embodied activity and thus for its departure from standard cognitive science's implicit commitment to the unembodied mind. This article offers a review of embodied cognition's recent empirical and theoretical contributions and suggests how this movement has moved beyond standard cognitive science. The article then clarifies important respects in which embodied cognition (...) has not departed fundamentally from the standard view. A shared commitment to representationalism, and ultimately, mechanism, suggest that the standard and embodied cognition movements are more closely related than is commonly acknowledged. Arguments against representationalism and mechanism are reviewed and an alternative position that does not entail these conceptual undergirdings is offered. (shrink)

Nonhuman primates represent an important reservoir for the transmission of new infectious diseases to humans. While several working groups and international agencies have grappled with the ethics of xenotransplantation, the Nuffield Council on Bioethics have recently published a comprehensive and far-reaching series of recommendations that, while not eliminating the infectious disease risks, have nonetheless detailed the major points for concern and have developed a rational approach to minimizing these risks. This report should serve as the blueprint from which to proceed (...) with xenotransplantation. (shrink)

We examined the affective consequences of everyday attention lapses and memory failures. Significant associations were found between self-report measures of attention lapses , attention-related cognitive errors , and memory failures , on the one hand, and boredom and depression , on the other. Regression analyses confirmed previous findings that the ARCES partially mediates the relation between the MAAS-LO and MFS. Further regression analyses also indicated that the association between the ARCES and BPS was entirely accounted for by the MAAS-LO and (...) MFS, as was that between the ARCES and BDI-II. Structural modeling revealed the associations to be optimally explained by the MAAS-LO and MFS influencing the BPS and BDI-II, contrary to current conceptions of attention and memory problems as consequences of affective dysfunction. A lack of conscious awareness of one’s actions, signaled by the propensity to experience brief lapses of attention and related memory failures, is thus seen as having significant consequences in terms of long-term affective well-being. (shrink)

In this essay, I argue that Robert Boyle does not hold that true religion requires us to believe doctrines that are in violation of the law of noncontradictionor that it yields logical contradictions. Rather, due to the epistemological limitations of human reason, we are sometimes called to believe doctrines orpropositions that are at first blush contradictory but, upon further inspection, not definitively so. This holds for doctrines considered singly or together and is animportant qualifier to the traditional line of scholarship’s (...) flat claim that Boyle’s limits of belief are logical contradictions. My conclusions here are at odds withJan W. Wojcik’s claim, in her important, revisionist work on the famous natural philosopher, that he teaches that sometimes we are required to believe religiousdoctrines that violate the law of noncontradiction. (shrink)

People may exhibit two kinds of modifications when demonstrating action for others: modifications to facilitate bottom‐up, or sensory‐based processing; and modifications to facilitate top‐down, or knowledge‐based processing. The current study examined actors' production of such modifications in action demonstrations for audiences that differed in their capacity for intentional reasoning. Actors' demonstrations of complex actions for a non‐anthropomorphic computer system and for people (adult and toddler) were compared. Evidence was found for greater highlighting of top‐down modifications in the demonstrations for the (...) human audiences versus the computer audience. Conversely, participants highlighted simple perceptual modifications for the computer audience, producing more punctuated and wider ranging motions. This study suggests that people consider differences in their audiences when demonstrating action. (shrink)

This chapter serves as an introduction to the book, offering a description of problems in Lockean scholarship, the book's overall argument and approach, and more. Locke scholarship tends to be compartmentalized, which is problematic since Locke was a systematic polymath. Scholarship also tends to over-simplify the intense debates in which Locke found himself. Furthermore, scholars typically fail to make a distinction between Locke's programmatic and personal views. As a result of these tendencies, some label Locke as heterodox, others as orthodox, (...) and still others try to identify him as defending a particular sect, all depending on the narrative or issue the scholar is exploring. Most Lockean scholars approach him as being religiously surreptitious, sectarian, or sincere. This book adds to the voices that think Locke was forthright in his writings. This chapter also articulates the thesis for the entire book and the theses and coherence of the following chapters. (shrink)

It is my contention here that the chapter “Of Power,” in John Locke’s An Essay Concerning Human Understanding, is not a metaphysical pronouncement upon the liberty-necessity debates but more along the lines of what those like James Harris portray it to be: a description of our experience of freedom of the will. It is also prescriptive since it is descriptive of the right use of the will. My claims are based upon two key pieces of evidence that are responses to (...) William Molyneux’s oft noted critique of the first edition of the chapter: 1) an admission by Locke in his correspondence: at least part of the reason he is attempting to avoid metaphysical pronouncements is that trying to reconcile divine and human agency is too difficult; and 2) the theological message of “Of Power”—the truly free agent is reasonable, and the truly reasonable agent will have her eyes fixed on the afterlife, thus aiming for herself to be a slave and determined, therefore, by her ever-cultivated desire for righteousness and not by her fleshly desires—and his development of it throughout the chapter eludes sectarian categorization by the avoidance of theological issues that are not unrelated to the metaphysical question of human free agency. To frame his chapter otherwise makes him out to be a theological novice or, perhaps, unconcerned with the religious background of his readership. (shrink)

This essay argues that Locke’s presentation of justification and the soteriological framework in which it is placed in The Reasonableness of Christianity is broad enough to encompass all “Christian” views on the topics except antinomian ones. In other words, the focus of the treatise is not Locke’s personal views of justification and the broader doctrine of salvation but an ecumenical statement of them. Locke’s personal conclusions on certain theological issues discussed in the opening pages of The Reasonableness of Christianity has (...) led most to assume that the soteriological discussion that follows reveals Locke’s own personal theological position despite clear indications of his ecumenical intent in The Reasonableness of Christianity and elsewhere. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Buddhist-Christian Studies 23 (2003) 189-193 [Access article in PDF] Buddhist Learning and Textual Practice in Eighteenth-Century Lankan Monastic Culture. By Anne M. Blackburn. Princeton, N.J.: Princeton University Press, 2001. x + 241 pp. Buddhist Learning is an important study of the emergence of the Siyam Nikaya (monastic order) in eighteenth-century Kandy, Sri Lanka's last Buddhist kingdom (which fell to the British only in 1815). Blackburn focuses on educational institutions (...) in her account, but frames it also to address larger issues in the study of Buddhist and non-Buddhist texts and history.An introductory chapter sets forth Blackburn's three central arguments (4): colonial and postcolonial scholarly constructions of Sri Lankan Buddhist "tradition" obscure the eighteenth-century phenomena that she reconstructs; the idea of "textual communities," developed in dialogue with contemporary scholarship on medieval European Christianity, provides a useful tool for analyzing those phenomena; [End Page 189] thus analyzed, the early Siyam Nikaya turns out to represent an innovative "reformulation" of Sri Lankan Buddhism, made possible by the establishment of the order itself, its systematization of monastic education, and the development of a bilingual commentarial genre for use within that system.Chapter 2 provides nonspecialists "at least a glimpse of the larger social context in which the emerging Siyam Nikaya participated" (23), with brief sketches of Sri Lankan Buddhist history, the structure and politics of the Kandyan court, the organization of monasticism prior to the rise of the Siyam Nikaya, and the presence of non-Buddhist religious leaders in Kandyan society. Chapter 3 begins with a discussion of Sri Lankan monastic education prior to 1730, then analyzes three stages in the emergence of distinctive Siyam Nikaya educational institutions (the early career of founder Valivita Saranamkara [1698-1778]; the late 1730s creation of a prototypical educational institution at Niyamakanda; and the 1753 importation of higher ordination [ upasampada ] from Thailand/formal establishment of the Siyam Nikaya, respectively), the history of royal patronage of these institutions, their new curriculum, its implementation and administration, its impact on monastic identity and lay-monastic relations, and the relationship of monastic erudition to prestige and patronage.Chapter 4 surveys Siyam Nikaya histories to argue that the order's rise was attended by "an innovative discourse on monasticism" that bolstered its authority by depicting its education-based interpretation of monastic virtue as "natural and desirable Buddhist practice" (105). Though these histories employed the rhetorical trope of decline and revival, their emphasis on Buddhist learning "signals a moment of profound change in Lankan Buddhism" (76-77), because they provided a charter for the new Nikaya while creating a perception that Siyam Nikaya monks practiced the best form of Buddhist monasticism. When imbibed by members of the royal court, this assured these monks steady patronage and prestige over their rivals, called ganinnanses, whom they directly and indirectly attacked. Chapter 5 zeroes in on Saranamkara and his Sararthadipani, a bilingual (Sinhala and Pali) commentary on the "four recitation sections" (catubhanavara) of protective (paritta) texts in Pali. This monumental work and the genre of bilingual commentaries (called sutra sannayas ) that it inspired, Blackburn maintains, were central to Saranamkara's claim to authority and created a distinctive monastic identity for Siyam Nikaya monks. Through close analysis of selected passages from Sararthadipani, Blackburn reveals the inner workings of bilingual commentary, particularly insofar as it allowed Saranamkara and his disciples to demonstrate their proper command of the classic Pali texts.In chapter 6 Blackburn argues that the sutra sannayas produced "a new Buddhist textual community" united in its reading and/or hearing of them. Exploring the ways in which Sararthadipani and the other sutra sannayas "constrained" readers to accept Saranamkara's vision of proper monasticism (such as direct instructions to readers and rhetorical structures), but recognizing that they also left open (in their use of simile, metaphor, and illustrative stories) the possibility of "less constrained" and "resistant" readings, Blackburn suggests that the genre extended the Siyam Nikaya's program beyond the small circle of Saranamkara's disciples to transform Sri Lankan monasticism [End Page 190] more generally. Moreover, she argues that given... (shrink)

In this essay, I argue that Robert Boyle does not hold that true religion requires us to believe doctrines that are in violation of the law of noncontradiction or that it yields logical contradictions. Rather, due to the epistemological limitations of human reason, we are sometimes called to believe doctrines or propositions that are at first blush contradictory but, upon further inspection, not definitively so. This holds for doctrines considered singly or together and is an important qualifier to the traditional (...) line of scholarship’s flat claim that Boyle’s limits of belief are logical contradictions. My conclusions here are at odds with Jan W. Wojcik’s claim, in her important, revisionist work on the famous natural philosopher, that he teaches that sometimes we are required to believe religious doctrines that violate the law of noncontradiction. (shrink)

In this article I argue that the 1729 Dissertation on Liberty and Neces­sity should be attributed to Anthony Collins. This was the prevailing view until the publication of James O’Higgins’s 1970 biography of Collins. Since then, most have followed Collins’s modern-day biographer in denying that Collins penned the Dissertation. After reviewing O’Higgins’s six reasons for rejecting Collins as the author, I respond to the substantive issues in what follows. Part I is a historical positioning of the Clarke-Collins liberty-necessity debate where (...) I discuss the debate’s context, Collins’s methods and disposition, and timeline issues pertinent to ascribing authorship of the Dissertation to Collins. Part II is a demonstration of the fittingness of the Dissertation as Collins’s response to the earlier debate regarding liberty and necessity he had with Samuel Clarke. (shrink)

In this article I argue that the 1729 Dissertation on Liberty and Neces­sity should be attributed to Anthony Collins. This was the prevailing view until the publication of James O’Higgins’s 1970 biography of Collins. Since then, most have followed Collins’s modern-day biographer in denying that Collins penned the Dissertation. After reviewing O’Higgins’s six reasons for rejecting Collins as the author, I respond to the substantive issues in what follows. Part I is a historical positioning of the Clarke-Collins liberty-necessity debate where (...) I discuss the debate’s context, Collins’s methods and disposition, and timeline issues pertinent to ascribing authorship of the Dissertation to Collins. Part II is a demonstration of the fittingness of the Dissertation as Collins’s response to the earlier debate regarding liberty and necessity he had with Samuel Clarke. (shrink)

In a series of important papers published roughly twenty years ago, Professor Robert Cooter developed a comprehensive economic theory of moral norms. He explained the value of those norms, described the process by which norms are adopted, and offered a set of predictions regarding the circumstances under which an individual will choose to adopt a particular moral norm. This brief Article applies behavioral law and economics and hedonic psychology to expand upon Professor Cooter’s path-breaking theory. In particular, understanding welfare in (...) hedonic terms — rather than preference-satisfaction terms — suggests a multitude of further situations in which individuals will justifiably seek to internalize moral norms. The hedonic approach to welfare then further suggests an enhanced role for the government to play in encouraging the adoption of welfare-enhancing norms. Cooter’s theory, combined with modern understandings of welfare and human behavior, thus offers powerful predictive and prescriptive possibilities. (shrink)

In the final years of his life, Emanuel Swedenborg wrote _True Christianity_, an opus that served both to contextualize his theology within contemporary Christianity and to serve as a road map for the new spiritual age that would follow. This second volume covers topics such as freedom of choice, repentance, the transformation of a person’s inner being during spiritual awakening, the rites of baptism and the Holy Supper, and the second coming of the Lord. This new translation is part of (...) the New Century Edition of the Works of Emanuel Swedenborg, an ongoing project to render Swedenborg’s theological works in clear, contemporary language that reflects the simple and engaging style of the original Latin. The portable edition contains the text of the New Century Edition translation, but not the annotations or other supplementary materials found in the deluxe edition. (shrink)

The Babylonian Talmud has reached us in multiple versions in medieval manu- scripts, early printed editions, and in citations in the works of medieval and early modern scholars. The field of Talmud criticism has developed criteria for working with these materials and the scholar E. S. Rosenthal famously theorized about the implications of textual variants for the history of the Talmud’s redaction. Tractate Temurah of the Babylonian Talmud received special attention due to the frequency and, at times, unique usage of (...) the term, lishana ’aḥarina, meaning “alternative textual reading,” found in it. In Temurah the term lishana ’aḥarina does not only signal a difference in formulation, as in other tractates of the Talmud, but some- times also seems to introduce a separately redacted text of the tractate that was integrated into a widespread and known base text. (shrink)

A brief self-report scale was developed to assess everyday performance failures arising directly or primarily from brief failures of sustained attention . The ARCES was found to be associated with a more direct measure of propensity to attention lapses and to errors on an existing behavioral measure of sustained attention . Although the ARCES and MAAS were highly correlated, structural modelling revealed the ARCES was more directly related to SART errors and the MAAS to SART RTs, which have been hypothesized (...) to directly reflect the lapses of attention that lead to SART errors. Thus, the MAAS and SART RTs appear to directly reflect attention lapses, whereas the ARCES and SART errors reflect the mistakes these lapses are thought to cause. Boredom proneness was also assessed by the BPS, as a separate consequence of a propensity to attention lapses. Although the ARCES was significantly associated with the BPS, this association was entirely accounted for by the MAAS, suggesting that performance errors and boredom are separate consequences of lapses in attention. A tendency to even extraordinarily brief attention lapses on the order of milliseconds may have far-reaching consequences not only for safe and efficient task performance but also for sustaining the motivation to persist in and enjoy these tasks. (shrink)

We report a novel task designed to elicit transient attention-lapse induced alienation of agency experiences in normal participants. When attention-related action slips occur during the task, participants reported substantially decreased self control as well as a high degree of perceived agency attributed to the errant hand. In addition, participants reported being surprised by, and annoyed with, the actions of the errant hand. We argue that ALIA experiences occur because of constraints imposed by the close and precise temporal relations between intention (...) formation and a contrary action employed in this paradigm. We note similarities between ALIA experiences and anarchic hand sign and argue that, despite important differences, both ALIA experiences and AHS phenomenology reflect failures of executive control to intervene and cancel contrary affordance-driven habitual motor plans. (shrink)

Legal Fictions: Studies of Law and Narrative in the Discursive Worlds of Ancient Jewish Sectarians and Sages. By Steven D. Fraade. Supplements to the Journal for the Study of Judaism, vol. 147. Leiden: Brill, 2011. Pp. xix + 627. $251.